Sirtuins are proteins that are part of a complex network of enzymes and genes that regulate our metabolism and energy metabolism. They are involved in several processes in the body, including lowering inflammation, improving insulin sensitivity and protecting our cells from damage.
There are seven different sirtuins (SIRT1 to SIRT7), each with their own functions. SIRT1 is the best known sirtuin and is associated with many of the health benefits associated with it sirtuin activation are attributed.
How does sirtuin activation work?
Sirtuin activation can be achieved in several ways, such as through calorie restriction, exercise and specific nutrients. Resveratrol, a substance found in red wine and grapes, is a well-known one sirtuin activator. It works by stimulating the activity of SIRT1, which can lead to improved metabolism and delayed aging.
Another way to Sirtuins can be activated by increasing nicotinamide adenine dinucleotide (NAD+) levels. NAD+ is a coenzyme necessary for the activity of sirtuins and is naturally produced in our bodies. However, NAD+ levels decrease as we age, which may be why sirtuin activity decreases as we get older.
There are several ways to increase NAD+ levels, including supplementation with nicotinamide mononucleotide (NMN). These compounds are converted into NAD+ in the body, which can lead to improved performance sirtuin activity and possible health benefits.
The pro's of sirtuin activation
Sirtuin activation may provide several health and longevity benefits, including:
- Delayed aging: Sirtuin activation can slow cell aging and extend lifespan, as shown in animal studies.
- Improved Metabolic Health: Sirtuin activation can improve insulin sensitivity and substance.
Although more research is needed, it has been proven that NMN reduces DNA damage and accumulation of oxidative stress people . Both characteristics are associated with longer healthy lives.